TNF and rheumatoid arthritis: In a post-approval comparative safety study using the US Corrona RA Registry, an ongoing longitudinal clinical registry from November 2012 through July 2018 (1999 tofacitinib initiators and 8358 TNF-inhibitor initiators), the IRs of VTE per 100 patient-years were 0.29 in tofacitinib initiators (5 mg twice daily in most cases) and 0.33 in bDMARD initiators, which were numerically similar between tofacitinib initiators and bDMARD initiators [75].