Consistent with a proinflammatory state, several key cell surface antigens (Cd4, Cd68, Cd84), immune sensors (Cx3cr1, Clec7a), and macrophage genes (Axl, Slc11a1) were upregulated in hIAPP islets and in type 2 diabetes. The gene discussed is CX3CR1; the disease is type 2 diabetes mellitus.