After integrating EBV DNA status and TNM stage, nonmetastatic NPC cases were categorized into RPA-I (T1-3N0 or EBV DNA–negative T1-3N1 cancers), RPA-II (EBV DNA–positive T1-3N1-2 or EBV DNA–negative T1-3N2-3/T4N0-3 cancers), and RPA-III (EBV DNA–positive T4N0-3/T1-3N3 cancers) groups, each with distinctly different prognosis. Here, RPA1 is linked to cancer.