In a preclinical study, the combination of anti-VEGFR2 and anti-PD-L1 antibodies promoted tumor cell destruction by inducing HEV formation and facilitating CTL infiltration and activity in PyMT (polyoma middle T oncoprotein) breast cancer and RT2-PNET (Rip1-Tag2 pancreatic neuroendocrine tumors)-bearing mice. The gene discussed is CD274; the disease is neoplasm.