For instance, uptake of oral antigens by MR has been shown to elicit tolerogenic responses following cross-presentation to CD8+T cells.63, 66Furthermore, antigen presentation by LSEC is known to induce CD8+T cell tolerance via upregulation of co-inhibitory molecule programmed cell death ligand-1.67Notably, this has also been shown for tumor antigens, which led to tumor-specific CD8+T cell tolerance.68, 69This suggests that under physiological conditions, LSEC antigen presentation is important for maintaining liver tolerance, but that this could prove detrimental in a neoplastic context. The gene discussed is CD8A; the disease is neoplasm.