NR3C2 and hepatocellular carcinoma: Nevertheless, MR is known to directly bind tumoral mucins and this is speculated to drive immunosuppression by interleukin (IL)-10-mediated Treginduction and downregulation of IL-12.160, 161Furthermore, targeting of TAM-expressed MR with a synthetic peptide analogue in murine xenograft models resulted in M2 macrophage reprogramming to an antitumor “M1” phenotype, as well as inducing apoptosis of the M2 TAM population.162These studies demonstrate the potential for targeting TAM-expressed MR in the context of HCC and future studies should explore this possibility.