Similarly, the intratumoral expression of another scavenger receptor, MARCO, has been shown to be associated with better patient prognosis186and its overexpression in hepatoma cell lines appeared to inhibit their migration and invasive properties, inducing apoptosis both in vitro and in vivo.186However, unlike ASGR1, which seems to be exclusively expressed on hepatocytes and HCC tumor cells, the expression of MARCO is also well known to be largely expressed by hepatic macrophages187, 188; therefore, more in-depth studies are required. This evidence concerns the gene ASGR1 and hepatocellular carcinoma.