In addition, basic levels of IL‐6 and TNF‐α in mDCs, and basic levels of IFN‐γ and TNF‐α in pDCs were increased in the elderly,44 while chronic low‐grade inflammation (slight increase of inflammatory factors, such as IL‐6 and TNF‐α), atherosclerotic cardiovascular and cerebrovascular diseases, Parkinson's disease, Alzheimer's disease, and other neurodegenerative diseases are closely related to the occurrence of malignant tumors.64 This evidence concerns the gene TNF and early-onset autosomal dominant Alzheimer disease.