T2DM patients had higher levels of chemerin than HC older adults (T2DM vs HC, 136.39 ± 20.98 vs 56.99 ± 10.07 ng/mL, P < .05) and lower levels of adiponectin were detected in T2DM patients (T2DM vs HC, 12.75 ± 4.56 vs 20.64 ± 2.52 μg/mL, P < .05). The gene discussed is RARRES2; the disease is type 2 diabetes mellitus.