In this study, the co-expression of CXCR5 in CAR-T was designed to not only increase the infiltration of CAR-T cells but also to mitigate potential off-tumor toxicity, due to our results that CAR-T only infiltrates into EGFR and CXCL13 double-positive tumor sites and produces a killing effect. Here, CXCR5 is linked to neoplasm.