reported that TILs plus IL-2 therapy after a lymphodepleting regimen of cyclophosphamide and fludarabine induced early high fever, diffuse rash, hearing loss, and bilateral anterior uveitis, which developed acutely in the patients with metastatic melanoma, and late autoimmune sequelae included the development of alopecia, vitiligo, poliosis, and bilateral panuveitis with diffuse retinal pigment epithelium (RPE) hypopigmentation, reminiscent of Vogt-Koyanagi-Harada (VKH) syndrome. This evidence concerns the gene IL2 and metastatic melanoma.