They found that compared to peripheral blood, CD4+ cells were significantly less predominant in tumor tissue (p = 0.0013) and there was a statistically significant (p = 0.0004) reversal of the ratio of CD4+ and CD8+ cells in the tumor tissue (0.68 ± 0.39) compared to peripheral blood (1.5 ± 0.66), with maximal alteration in higher stage disease.90 Here, CD8A is linked to neoplasm.