A systematic review and meta-analysis on the prognostic significance of intra-tumoral CD3+ and CD8+ lymphocytes showed that both TILs had a positive effect on patient overall survival (OS) of cervical cancer with a hazard ratio (HR) of 0.58 and 0.71, respectively, for death,65 highlighting that CD3+ and CD8+ TILs have prognostic values not only for cancer progression but also patient OS. This evidence concerns the gene CD8A and cancer.