IL2 and colon adenocarcinoma: reported a C57BL/6 mouse metastasis model, where 4 × 106 to 5 × 106 TILs combined with IL-2 could eliminate 96% of micro-metastases, and under the combined action of cyclophosphamide and TILs, together with IL-2, had a cure rate of 100% for late liver metastasis and 50% for lung metastasis in mice (n = 12) carrying MC-38 colon adenocarcinoma.