In a multivariate Cox analysis, a low CD8+/Treg ratio (p = 0.047), weak HLA-A-MICA expression (p = 0.003), and weak HLA-A-MICA expression combined with a low CD8+/Treg ratio (p = 0.002) were all found to be independent unfavorable predictors in cervical carcinoma (HR = 2.7, 4.0, and 4.9, respectively).92 This evidence concerns the gene CD8A and cervical carcinoma.