The injection of WR/TK−/3Δ increased T cell reactivity to all the three epitopes (Figure 6B); however, of note, we found clearly increased levels of epitope-specific IFN-γ-producing T cells directed against the tumor antigens (gp100 and B16-M30) compared to treatments with the parental virus WR/TK−. Here, IFNG is linked to neoplasm.