SFN and cancer: The SFN gene encodes a cell cycle checkpoint protein that binds to translation and initiation factors and functions as a regulator of mitotic translation.5, 6, 7, 8 SFN has been reported as an oncogene in several cancers, including ovarian cancer and NSCLC.9, 10, 11 However, it is not clear how it influences drug sensitivity in NSCLC patients.