CD4 and metabolic dysfunction-associated steatotic liver disease: Furthermore, the clearance of CD4+ T cells was shown to reduce liver inflammation and fibrosis in mice, and a study by Rau et al. highlighted an increase in CD4+ memory T cells at sites of intrahepatic fibrosis in patients with NAFLD, demonstrating that CD4+ memory T cell subsets are important drivers of progression from steatosis to fibrosis in NAFLD.