TLR2 and colorectal carcinoma: Zhu et al. [105] had reported that a significant association was found between the TLR2 −196 to −174 del and cancer risk; however, it was restricted to only a subgroup of Caucasian and south Asians and not among east Asians, while Proenca et al. Proenca et al. [5] reported that TLR2 -196 to -174 del polymorphism results in the increase in the TLR2 mRNA expression which is associated with a higher risk of developing CRC.