As previous studies, up-regulated LBX2-AS1 has been found in gastric cancer (Yang et al., 2020), ovarian cancer (Cao et al., 2021), esophageal squamous cell carcinoma (Zhang et al., 2019) as well as hepatocellular carcinoma (Wang et al., 2020c). Here, LBX2 is linked to esophageal squamous cell carcinoma.