TRIM21 and familial long QT syndrome: Mounting evidence from clinical and experimental studies indicates that anti-Ro/SSA-antibodies can markedly affect the ventricular repolarization via a direct inhibitory cross-reaction with the extracellular pore region of the cardiac hERG-K+-channel, resulting in an increased predisposition to LQTS/TdP in anti-Ro/SSA-positive patients.