The first evidence was provided by Nakamura et al. (33) who demonstrated that serum and purified IgGs from an otherwise healthy anti-Ro/SSA-positive woman presenting with marked QTc prolongation and recurring TdP, cross-reacted with the hERG-K+-channel and chronically blocked IKr in HEK293-hERG cells. The gene discussed is KCNH2; the disease is torsades de pointes.