Indeed, in agreement with current recommendations for incomplete forms of aCHB (100) (and with several case reports showing the reversing effects of immunosuppressive therapy in anti-Ro/SSA–associated atrioventricular blocks in adults) (101–104), preliminary data from anti-Ro/SSA-positive CTD patients suggest that a short course immunomodulating treatment with corticosteroids is associated with a significant QTc shortening (104, 105). The gene discussed is TRIM21; the disease is atrioventricular block.