Since Ang II triggers the release of extracellular CyPA through regulation of Rho-kinase and that extracellular CyPA behaves as a secreted oxidative stress molecule triggering the activation of the NF-κB that stimulates the transcription of VCAM-1 and E-selectin and the overexpression of TNFα the inhibition of CyPA with CsA in COVID-19 patients could reduce atherosclerosis, hypertension, and heart failure. This evidence concerns the gene TNF and COVID-19.