Interestingly, treatment of COVID-19 patients with a recombinant soluble human ACE2 (hrsACE2 from Apeiron Biologics, Vienna, Austria) which can interfere with virus binding but also with Ang II reduced SARS-CoV-2 load and induced a massive decrease of Ang II levels, IL-6, and TNF in patients and showed a strong benefit for the outcome of the patients (199) (Figure 7). The gene discussed is TNF; the disease is COVID-19.