Indeed, CypA secretion is regulated by Rho-kinase and behaves as a secreted oxidative stress molecule contributing to the pathogenesis of arteriosclerosis, hypertension, and heart failure, and inhibition of Rho-kinase by fasudil reduces the Ang II-induced aortic aneurysm formation (182, 183). The gene discussed is PPIA; the disease is Hypertension.