Of note, Gal-1-carrying TAMs significantly increased the serum level of Gal-1 in HCC-bearing mice, indicating that TAM-derived Gal-1 may contribute to systemic effects of Gal-1, for example, the systemic immunosuppression induced by circulating Gal-1 in tumor-bearing mice (Dalotto-Moreno et al., 2013). Here, LGALS1 is linked to hepatocellular carcinoma.