The toxic aggregation of tau in diseases like AD, PD, and other tauopathies seems to coincide with mitochondrial impairment associated with transport, dynamics and bioenergetics of the mitochondria (reviewed by Gibson et al., 2010; Eckert et al., 2011; Cabezas-Opazo et al., 2015; Pérez et al., 2018a). Here, MAPT is linked to Alzheimer disease.