However, tau aggregation is also implicated in other diseases including Pick’s disease, Cortico-basal degeneration, Progressive supranuclear palsy and Fronto-temporal dementia with Parkinsonism linked to chromosome 17 (Spillantini and Goedert, 1998; Lee et al., 2001; Goedert and Spillantini, 2011). Here, MAPT is linked to Classical progressive supranuclear palsy.