Lewy bodies, the α-synuclein-containing aggregates that are the pathological hallmark of PD, contain high lipid content and lipid membranes (Shahmoradian et al., 2019), while membrane lipids such as those associated with cholesterol have been associated with PHF in AD brains (Gellermann et al., 2006). The gene discussed is SNCA; the disease is Alzheimer disease.