Furthermore, two key genes are differentially expressed in CCs from PCOS patients, including LH/choriogonadotropin receptor and insulin receptor gene (Supplementary Table 6), which were identified as susceptibility genes for PCOS in previous GWAS and strongly associated with anovulation (Chen et al., 2011; Shi et al., 2012; Cui et al., 2015). Here, PLOD1 is linked to polycystic ovary syndrome.