Epigallocatechin-3-gallate (EGCG) decreases the glucose and lactate levels in cancer cells by reducing GLUT1 mRNA levels in 4T1 cell line (Wei et al., 2018), and cantharidin suppresses metastasis by inhibiting glucose uptake and lactate production through decreasing GLUT1 protein level in MCF-7 and MDA-MB-231 (Pan et al., 2019). The gene discussed is SLC2A1; the disease is cancer.