The anti-tumoral mechanism of polyphenols against breast cancer includes increased apoptosis, cell cycle arrest, enhanced autophagy, decreased angiogenesis, anti-inflammatory effect, blockade for estrogen, aromatase modulation, altered redox balance, and inhibition of the HER-2 pathway (Mocanu et al., 2015; Losada-Echeberría et al., 2017). The gene discussed is ERBB2; the disease is breast carcinoma.