ERBB2 and breast cancer: HIF-1α overexpression has been reported in breast cancer (Zhong et al., 1999), and it is attributed to the increased expression of glycolysis-related proteins in breast cancer because HIF-1α overexpression is related to HER-2 positivity (Giatromanolaki et al., 2004) and TNBC (Jin et al., 2016).