Additionally, 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 expression is related to the expression of vascular endothelial growth factor (VEGF)-α in breast cancer, which contributes to angiogenesis and distant metastasis (Peng et al., 2018). The gene discussed is PFKFB3; the disease is breast carcinoma.