PKM and breast carcinoma: Breast cancer shows an increased expression of glycolysis-related enzymes, namely, HKII (Brown et al., 2002; Yang T. et al., 2018), 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) (O’Neal et al., 2016), and pyruvate kinase M2 (PKM2) (Lin et al., 2015).