HIF1A and neoplasm: In general, TAMs exhibit properties of M2 macrophages (Mantovani et al., 2002; Hollmén et al., 2015), and TAMs in hypoxic tumor regions express HIF-1 (Burke et al., 2003), which controls the expression of glycolysis-related genes, including GLUT1, HK2, PFFB3, and PGK1 (Semenza et al., 1994).