MTOR and cancer: Molecules involved in the regulation of glucose metabolism in cancer in general are oncogenes such as Ras, Src, and MYC, transcription factors such as hypoxia-inducible factor-1 (HIF-1), signaling pathway such as phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), and tumor suppressor such as p53.