Of the total of 17 genes that were overexpressed in IND versus HD in one or more than one selected pathways, four of them (CSF2, IL2, IL5, and IL6) reached a log2 of FC > 1 and p < 0.05; in the IND versus HD subjects, four genes (CASP3, CD2, CD28 and IL12RB1) had factor loading with PC1 > 0.6 (the principal component responsible for the differences between both groups), and nine genes (BCL2, CD40, CD40LG, CSF1, FAS, IFNG, IL12RB2, IL7, and TNF) fulfilled the criteria for both tests. The gene discussed is CD40; the disease is Huntington disease.