CD28 and Huntington disease: Of the total of 17 genes that were overexpressed in IND versus HD in one or more than one selected pathways, four of them (CSF2, IL2, IL5, and IL6) reached a log2 of FC > 1 and p < 0.05; in the IND versus HD subjects, four genes (CASP3, CD2, CD28 and IL12RB1) had factor loading with PC1 > 0.6 (the principal component responsible for the differences between both groups), and nine genes (BCL2, CD40, CD40LG, CSF1, FAS, IFNG, IL12RB2, IL7, and TNF) fulfilled the criteria for both tests.