VEGFA and colorectal cancer: Some studies have found that there is a correlation between AEs of apatinib and the efficacy in treatment of gastric cancer, non-small cell lung cancer, colorectal cancer and liver cancer that may be due to the simultaneous expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptors in tumor tissues and normal tissues (23–27).