FGF1 and neoplasm: Moreover, FGF1 expression was significantly associated with lymph node metastasis (P = 0.003), tumor budding degree (P = 0.002) and TNM stage (P = 0.001, Table 2), while no correlation was observed with other clinicopathological variables such as age, gender, tumor size, the depth of invasion, degree of differentiation, venous invasion and neural invasion (P > 0.05, Table 2).