Expression of miR-210 might promote metastasis, and miR-206 had a suppressive role in MB viability and migration by targeting LASP1 and OTX2.122, 123, 124 Moreover, re-expression of miR-218 decreased cell growth, cell colony formation, cell migration, invasion, and tumor sphere size in MBs by directly regulating SH3GL1, and CDK6, RICTOR, and cathepsin B (CTSB) might be additional targets.125. This evidence concerns the gene CTSB and Mobius syndrome.