Prostate volume, PSA, residual voiding volume, bladder wall thickness, C-reactive protein (CRP), Aging Males’ Symptoms (AMS) scale, International Index of Erectile Function-erectile function (IIEF-EF) and IPSS were measured over the study period with anthropometric parameters of obesity, including weight, body mass index and waist circumference. The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.