Studies on interruption of TTh and resumption clearly showed the benefits on LUTS and voiding symptoms, where authors stated that interruption reduced TT to hypogonadal levels resulting in worsening of obesity parameters, AMS, IPSS, residual voiding volume and bladder wall thickness, IIEF-EF, and PSA while CRP and prostate volume were unchanged until treatment resumed whereby these effects were reversed. This evidence concerns the gene CRP and Obesity.