Since the formation of mature endosomes is necessary for the transduction of signals and transport of materials from the extracellular space to the intracellular environment (Murphy et al., 2009; Scita and Di Fiore, 2010), activated EGFR signaling caused by its high expression or constitutively activating mutation is expected to accelerate the endocytic process, which provides survival signals or nutrition for the growth and proliferation of cancer cells. This evidence concerns the gene EGFR and cancer.