The study shows that EZH2 dependent protein stability of LSD1, HDAC1, DNMT1, β-catenin, or SMAD2/4, via recruitment of deubiquitinase USP7, is key in suppressing neuronal genes and sustaining the expression of Wnt and TGFβ target genes in cancer cells (Lei et al., 2019). This evidence concerns the gene EZH2 and cancer.