DNMT1 and cancer: The study shows that EZH2 dependent protein stability of LSD1, HDAC1, DNMT1, β-catenin, or SMAD2/4, via recruitment of deubiquitinase USP7, is key in suppressing neuronal genes and sustaining the expression of Wnt and TGFβ target genes in cancer cells (Lei et al., 2019).