ITGAM and pneumococcal pneumonia: Albeit CD11b and CD62L are important for neutrophil migration, and Btk has been implicated in neutrophil adhesion to and crawling along endothelium and migration into tissue (23, 63, 64), the deviant expression levels of these adhesion molecules in unstimulated cells did not result in decreased neutrophil migration in Mrp8cre-Btkfl/Y mice upon pneumococcal pneumonia or LTA induced lung inflammation.