IFNAR1 and acute disseminated encephalomyelitis: Statistical analyses of both the survival and body weight demonstrated that both ZIKV-IG and 4G2 increased DENV2 disease in comparison to their respective controls and there were no statistical differences between treatment with 4G2 and ZIKV-IG, indicating that administration of a sub-neutralizing dose of ZIKV-IG to Ifnar1-/- mice one day prior to DENV infection resulted in an ADE-like disease as seen with pretreatment of 4G2.