IFNAR1 and acute disseminated encephalomyelitis: While it has been shown that ZIKV-IG is protective at doses equal to and greater than 10 mg/kg in ZIKV infected IFNAR1-/- mice (52), studies with DENV (38, 40) suggest that at non-sterilizing concentrations, a polyclonal hyperimmune serum such as ZIKV-IG could induce ADE.