Looking at the vaginal fluid of 27 women with PPROM without clinical chorioamnionitis between 22 to 36 (mean= 31.6) weeks of gestation, Dorfeuille et al. (15) measured MMP-8, interleukin-6 and the concentration of the metabolites lactate and glucose. This evidence concerns the gene MMP8 and preterm premature rupture of the membranes.