MAPK3 and Alzheimer disease: In this study, the 5-HT1B-mediated ERK1/2 phosphorylation by EG and the antifungal (Qi et al., 2005) as well as acetylcholinesterase I (AChE I)- inhibiting (Lin et al., 2015) activities of EG led us to investigate the EG and 5-HT1B interaction in the context of AD.