The adverse effects of TNF inhibitors mainly included infection, increased risk of TB and hepatitis B virus (HBV) infection, injection site reaction, abnormal liver function, severe allergic reaction, autoimmune disease, new onset of psoriasis, and tumors (Fouache et al., 2009; Maxwell et al., 2015; Ramiro et al., 2017; Webers et al., 2019). This evidence concerns the gene TNF and infection.