RUNX2 and metastatic prostate carcinoma: In addition, P-NET selected a hierarchy of pathways (out of 3,007 pathways on which P-NET was trained) as relevant to classification, including cell cycle checkpoints, post-translational modification (including ubiquitination and SUMOylation) and transcriptional regulation by RUNX2 and TP53. Multiple members of the cell cycle pathway have been functionally implicated in metastatic prostate cancer, and specifically functionally interrogated in treatment-resistant contexts27,28.