Top upregulated kinases in tumors include PRKRA and PRKDC in CCRCC, TLK1 and STK39 in CRC, MAPK15 and MAP2K4 in LUAD, PTK2B and NADK in OV, and PIK3C2A and MAPK15 in UCEC (Fig. 2c). The gene discussed is MAP2K4; the disease is colorectal carcinoma.