In CRC, the HIPPO pathway was correlated with hyperphosphorylation of its casein kinases at phosphosites CSNK1D p.T387 (R = 0.31, FDR = 0.025) and CSNK1E p.S363 (R = 0.43, FDR = 4.3e − 4). This evidence concerns the gene PDIK1L and colorectal carcinoma.