PRKRA and lung carcinoma: PRKRA showed the most significant expression-driven dependency (R = −0.46, FDR = 1E − 3) in lung cancer cell lines (Fig. 5a, b) and was overexpressed in 7% of LUAD cases, whereas its phosphosite PRKRA p.S130 is over-phosphorylated in 15% of LUAD.