As expected, PIK3CA showed the highest median genomic alteration rate (21%) across cancer types (Supplementary Fig. 4a), with varying protein overexpression rates across cancer types, including BRCA (Genomic alteration rate, DNA = 36%; PRO = 4%), OV (DNA = 24%, PRO = 6%), and UCEC (DNA = 51%, PRO = 1%), possibly reflecting the PIK3CA hotspot mutations that rarely co-occur with protein upregulation. The gene discussed is PIK3CA; the disease is cancer.