Using the CPTAC samples with concurrent genomic and phosphoproteomic data, we further conducted a multivariate linear regression (adjusted for age, sex, ethnicity, and MS batches) identifying protein kinase phosphosites whose expression were associated with their missense or truncating mutations, finding one significant association between DCLK1 missenses and DCLK1 p.S364 in CRC (logFC = 7.1, FDR = 0.021). The gene discussed is WEE1; the disease is colorectal carcinoma.