SHH and cervical squamous intraepithelial neoplasia: Indeed, our results point to a close, inhibitory cross talk between dopaminergic and Shh signaling in CIN (Fig. 8e) and suggest that the interruption of ShhDAN to SmoCIN signaling is not merely permissive for LID but is a critical mechanism by which LID-inducing CIN pathology is set in motion following the loss of DAN.