Among CD8+ T cells, the majority bear CCR7−CD45RA− effector memory T (Tem) and CCR7−CD45RA+ effector memory reexpressing CD45RA (Temra) phenotypes10–12, where the former preferentially expressed increased levels of PD-1, T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and 2B4, but not T-cell immunoglobulin mucin-3 (TIM-3) and lymphocyte-activation gene 3 (LAG-3) inhibitory receptors compared to other BC-infiltrating CD8+ T-cell subsets13. This evidence concerns the gene HAVCR2 and breast cancer.