While OLFM4 has not been shown to directly affect neutrophil functions such as phagocytosis or tissue migration, OLFM4+ neutrophil subsets have been found to be highly expanded and associated with mortality in inflammatory diseases with high mortality and morbidity such as sepsis, intestinal ischemia/ reperfusion injury 39 and, hemorrhagic shock. Here, OLFM4 is linked to Sepsis.