Such high CD177 gene upregulation was associated with significant increase in the corresponding neutrophil cell surface CD177 protein expression in ACLF compared to CLD and HC (~ 80% neutrophils in ACLF vs ~ 50% in CLD vs ~ 55% in healthy control; One way ANOVA p = 0.0002 and ACLF vs CLD p value < 0.0001) as captured by flow cytometric evaluation (Fig. 4C ). The gene discussed is CD177; the disease is congenital secretory chloride diarrhea 1.