GSEA analysis using MSigDB revealed the upregulation of the neutrophil degranulation pathway in ACLF versus CLD, supporting the observation that neutrophil granule genes ELANE and MPO and related cell surface protein CD177 were highly upregulated in ACLF PMN (Supplementary Table 10). The gene discussed is CD177; the disease is congenital secretory chloride diarrhea 1.