Percentage of CD177+ neutrophils in total CD16+CD66b+ neutrophils were found to be significantly higher in ACLF (~ 80%) as compared to CLD (~ 50%) (p value < 0.0001) and Healthy controls (~ 60%) (p value 0.005) (Fig. 4B,C). The gene discussed is CD177; the disease is congenital secretory chloride diarrhea 1.