To comprehensively examine expression of the IL-2R subunits, IL-2Rα (also called CD25), IL-2Rβ (CD122) and IL-2Rγ (CD132), in mature T-NHL, we performed immunostaining of TMA comprising angioimmunoblastic T-cell lymphoma (AITL, n = 8), peripheral T-cell lymphoma not otherwise specified (PTCL-NOS, n = 23), ALCL with (n = 22) or without (n = 23) ALK-translocation, and of non-neoplastic reactive lymph node controls (n = 11) as well as of pcALCL specimens (n = 24). The gene discussed is IL2RB; the disease is peripheral T-cell lymphoma, not otherwise specified.