The LD50 of ADCT-301-induced cell death was remarkably low (between 0.8 and 2.3 ng/ml) for ALCL cell lines, but >156 ng/ml in the IL-2Rα-negative cell lines (Fig. 4c), indicating the high efficacy and specificity of ADCT-301 for ALCL. The gene discussed is IL2RA; the disease is anaplastic large cell lymphoma.