Among the most significantly downregulated genes in 3 different CRISPR/Cas9-mediated BATF3-deleted clones was IL2RG (Supplementary Fig. 2a), and IL-2- together with in ALCL well-described IL-10- and STAT3-signaling was detected as being deregulated25,28 (Fig. 1e and Supplementary Fig. 2b). This evidence concerns the gene STAT3 and anaplastic large cell lymphoma.