When we tested the effect of ADCT-301 or control ADC B12-SG3249 on STAT1 and STAT5 levels in ALCL cell lines, we found reduction of pYSTAT5 in all tested cell lines and reduction of pYSTAT1 in the FE-PD cell line (Supplementary Fig. 6d). The gene discussed is STAT1; the disease is anaplastic large cell lymphoma.