Whereas the prognosis of adult ALCL, ALK+ and subgroups of ALCL, ALK− is usually good, relapses occur frequently in pediatric ALCL, ALK+, and the outcomes of patients with relapsed/refractory ALCL patients and advanced BIA-ALCL are rather poor, highlighting an unmet medical need for these patients2,7. The gene discussed is ALK; the disease is anaplastic large cell lymphoma.