As shown in Fig. 9A−C, we observed that the tumour weights and volumes obtained with KLK8-overexpressing cells were larger and the weights of the mice were lower than those obtained with the control cells, while the tumour volume in the PAR1 inhibition group was smaller than that in the KLK8 overexpression group (Fig. 9A−C). The gene discussed is F2R; the disease is neoplasm.