First, we analysed the expression of KLK8 in CRC patients using four independent public datasets from Oncomine (https://www.oncomine.org/resource/main.html) and found that KLK8 expression was elevated in CRC tissue samples compared to normal tissue samples (Supplementary Fig. S2, P < 0.0001). The gene discussed is KLK8; the disease is colorectal carcinoma.