To identify functional miRNA−mRNA interactions associated with KLK6-mediated invasiveness of colon cancer, Sells et al. [56] performed the integrated miRNA and mRNA expression profiling, and indicated that the established miRNA−mRNA interactions modulate cellular proliferation, differentiation and EMT in KLK6-expressing colon cancer cells via the TGF-β signalling pathway and RAS-related GTP-binding proteins. Here, TGFB1 is linked to colonic neoplasm.