Thus, the current study also detected the effects of MTDH on the expressions of E-Cadherin, N-Cadherin, and Vimentin in Gem-treated breast cancer cells, and found that silencing MTDH promoted expression of E-Cadherin and inhibited expressions of N-Cadherin and Vimentin in Gem-treated MCF7 cells (P < 0.01, P < 0.05, Fig. 4C). This evidence concerns the gene VIM and breast cancer.