Shahryari et al. [18] also reported the coregulation of SOX2OT and its new splicing variants SOX2OT-s1 and SOX2OT-s2 with key stem cell pluripotency genes SOX2 and OCT4, which are involved in the development of esophageal squamous cell carcinoma. Here, POU5F1 is linked to esophageal squamous cell carcinoma.