LRRK2 and Parkinsonism: Thus, the pathological hallmarks of LRRK2-parkinsonism, including increased LRRK2 kinase activity, aberrant α-synuclein expression and phosphorylation, impaired neurite outgrowth, and increased apoptosis in dopaminergic neurons carrying the LRRK2 c.G6055A (p.G2019S) mutation, were significantly mitigated by genomic editing using ABEs or HDR.