Thus, the pathological hallmarks of LRRK2-parkinsonism, including increased LRRK2 kinase activity, aberrant α-synuclein expression and phosphorylation, impaired neurite outgrowth, and increased apoptosis in dopaminergic neurons carrying the LRRK2 c.G6055A (p.G2019S) mutation, were significantly mitigated by genomic editing using ABEs or HDR. The gene discussed is LRRK2; the disease is Parkinson disease.