To ascertain the relationship between the previously identified differentially expressed genes (DEGs) in aged vs young or AD vs control brains and genes with altered alternative splicing patterns identified in the L-DL KD mouse brain, we next conducted overlapping analysis: DEGs were pulled out from (1) RNA-seq data of young vs old mouse brains (GSE129788), (2) RNA-seq data of APP/PS1 vs WT mouse brains (GSE132177), and (3) proteomic data of human AD brains [45]. The gene discussed is PSEN1; the disease is Alzheimer disease.