We therefore speculate that L-DL regulates the expression of multiple synapse- and cytoskeleton-related genes via modulating their RNA splicing process in AD brains of -.CAMKV Therefore, L-DL-mediated improvement in cognition in APP/PS1 mice is likely due to the restoration of multiple synaptic and cytoskeletal gene expression, beyond CAMKV, via changing the alternative splicing patterns of these genes. This evidence concerns the gene APP and Alzheimer disease.