The Hp biomarker in experimentally infected cattle appeared to be a good predictor biomarker of the infection, as the first peak of Hp levels at 10 dpi appeared simultaneously in all infected groups and coincided with the incubation period and enlarged lymph nodules just prior to fever development (between 7 and 24 dpi) [17], except for the subcutaneously inoculated group, which presented fever at 7 dpi. This evidence concerns the gene HP and Fever.