The criteria include the following standards: one mandatory criterion that angiographic abnormality should be proved by imaging studies, plus one of the following: absent/weak or unequal peripheral arterial pulses, discrepancy of four limb systolic blood pressure measurements of more than 10 mmHg difference in any limb, bruits over large arteries, hypertension, and raised acute phase reactant (ESR < 20 or elevated CRP) [13]. This evidence concerns the gene CRP and hypertensive disorder.