PKM and hepatocellular carcinoma: Hence, we propose that LNCAROD exerts its oncogenic role in HCC by elevating PKM2 levels through a two-fold mechanism: (a) increasing PKM2 expression in the nucleus via SRSF3-mediated PKM alternative splicing and (b) maintaining PKM2 level in the cytoplasm by functioning as a ceRNA for miR-145-5p.