AKT1 and hepatocellular carcinoma: For example, lncRNA PICSAR upregulated the eukaryotic initiation factor 6 (EIF6) by functioning as a ceRNA and sponging miR-588 in HCC cells, thus causing PI3K/AKT/mTOR activation to mediate HCC cell proliferation, colony formation, cell cycle progression, and apoptosis inhibition [11].