In general, four sing have been applied for the occurrence of PCOS: (a) an abnormal morphology of the ovaries [4], (b) an overproduction of androgens from ovaries [5], (c) a functional defect in the hypothalamic-pituitary axis and an increase in the secretion of LH/FSH [6], and (d) insulin resistance and hyperinsulinemia [7]. The gene discussed is PLOD1; the disease is Insulin resistance.