In another animal study, Sadoughi et al. found that GTE administration over 24 days led to a statistically significant decrease in serum levels of LH, β-estradiol, and testosterone in PCOS model rats, as well as improved ovarian function (Significant increase in the number of preantral, antral, prehavulatory and corpus luteum follicles and also caused a significant decrease in the number of cystic follicles), FSH, and progesterone levels, were also reported [21]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.