Such T2DM patients have been demonstrated to have a 14–25% decreased lag-time, 16–23% shorter time-to-peak, 15–45% increased peak thrombin concentration, and 15–28% increased endogenous thrombin potential (depending on the coagulation trigger and presence of thrombomodulin) when compared to control subjects [70]. Here, THBD is linked to type 2 diabetes mellitus.