Most importantly, elevated circulating markers of NETs, defined as citrullinated histone H3 and cell-free DNA in the top quartiles, have been found to predict clot lysis time when assessed by the Lisman method in T2DM patients, accompanied by CVD and other important modulators of fibrinolysis such as PAI-1 [58]. The gene discussed is SERPINE1; the disease is type 2 diabetes mellitus.