PLG and type 2 diabetes mellitus: In vitro, after incubation of α2-antiplasmin with glucose at concentrations encountered in T2DM, eleven glycation sites have been identified on α2-antiplasmin, including on four (K-418, K-427, K-434, K-441) out of six lysine residues, known to be important for mediating the interaction with plasmin [106], the biological significance of these glycations remains to be established.