We determined that EAC cell lines OE19, OE33, FLO1, SKGT2, and EAC42 overexpressed all the INT subunits examined (INTS1, 3, 6, 9, 10, 11, 13) as compared to the non-tumorigenic esophageal cell line Het1A, indicating the importance of INT in these cancer cells (Fig. 3a). The gene discussed is INTU; the disease is cancer.