CD274 and pachyonychia congenita: Among IIIA-B stage (HR = 2.64, 95% CI 1.03–6.78, P = 0.043), PD-L1 positive (HR = 4.74, 95% CI 1.04–21.63, P = 0.045) PC GC patients, gene rearrangement was a negative factor for overall survival (Fig. 2b).